头孢菌素酯。第三部分。头孢呋辛1-乙酰氧基乙酯R和S异构体的分离及性质
Esters of cephalosporins. Part III. Separation and properties of the R and S isomers of the 1-acetoxyethyl ester of cefuroxime.
作者信息
Oszczapowicz I, Małafiej E, Horoszewicz-Małafiej A, Szelachowska M, Kuklewicz C, Sierańska E
机构信息
Department of Modified Antibiotics, Institute of Biotechnology and Antibiotics, Warsaw, Poland.
出版信息
Acta Pol Pharm. 1995 Nov-Dec;52(6):471-6.
PMID:8960265
Abstract
Two separation methods for the R and S isomers of the 1-acetoxyethyl ester of cefuroxime [I] were evaluated. Physico-chemical and biological properties of these isomers were studied. It was found that the R isomer after oral administration to rats is absorbed better and faster than the isomer S.
摘要
对头孢呋辛1-乙酰氧基乙酯[I]的R和S异构体的两种分离方法进行了评估。研究了这些异构体的物理化学和生物学性质。发现给大鼠口服后，R异构体比S异构体吸收得更好更快。
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