Vitková Z, Gardavská K, Cizmárik J, Rak J
Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.
Acta Pol Pharm. 1995 Nov-Dec;52(6):483-5.
The influence of glycerol, propylene glycol and sorbitol on surface tension, partition coefficient and diffusion of pyrrolidinoethylester of 3-heptyloxy phenylcarbamic acid (Drug XX Z) from solutions has been studied. It was found that each of the three mentioned auxiliary substances causes, proportionally to its concentration (5, 10, 15 and 20%), the increase of the surface tension and the decrease of the partition coefficient. A correlation between the surface tension and partition coefficient was proved. The diffusion of the drug XX Z was increased due to use of the auxiliary substances. With respect to these results and in accordance with the rules for development of the drug form, sorbitol in concentration 5-10% seems to be an optimal auxiliary substance.
研究了甘油、丙二醇和山梨醇对3-庚氧基苯基氨基甲酸吡咯烷基乙酯（药物XX Z）溶液的表面张力、分配系数和扩散的影响。发现上述三种辅助物质中的每一种都会随着其浓度（5%、10%、15%和20%）成比例地导致表面张力增加和分配系数降低。证明了表面张力和分配系数之间的相关性。由于使用了辅助物质，药物XX Z的扩散增加。基于这些结果并根据药物剂型的开发规则，浓度为5-10%的山梨醇似乎是一种最佳辅助物质。
