Ciszewska-Jedrasik M, Knyt A, Pertkiewicz M
Department of Applied Pharmacy, Drug Science Institute, School of Medicine, Warsaw, Poland.
Acta Pol Pharm. 1995 Nov-Dec;52(6):487-90.
Aminophylline stability (dose 0.5 and 0.75 g) was estimated in typical AIO nutrient admixtures [Salviamin 12.5% 1000.0 cm3; Glucose 500 g; Intralipid 20% 500.0 cm3; Soluvit N; Vitalipid N Adult; Addamel N; total volume 3000.0 cm3] prepared in DIMIX bags [Diffuplast srl, Italy]. The pH. particle size distribution [Coulter Counter ZM] and theophylline concentration [Spectrophotometer Pye Unicam] were measured immediately after preparation and after 24, 48, 72 hours of storage in low temperature and then after 24 hours in room temperature. Aminophylline proved to be stable in above mentioned doses and now is commonly added into AIO in practice.
在[意大利Diffuplast srl公司生产的]DIMIX袋中制备的典型全合一营养混合液[12.5% 1000.0 cm³ 的Salviamin；500 g葡萄糖；20% 500.0 cm³ 的Intralipid；Soluvit N；成人用Vitalipid N；Addamel N；总体积3000.0 cm³]中评估了氨茶碱（剂量为0.5和0.75 g）的稳定性。在制备后以及在低温下储存24、48、72小时后，然后在室温下储存24小时后，立即测量pH值、粒度分布[库尔特计数器ZM]和茶碱浓度[派伊尤尼卡分光光度计]。结果证明，上述剂量的氨茶碱是稳定的，目前在实际应用中通常将其添加到全合一营养混合液中。
