Braeckman L, De Bacquer D, Rosseneu M, De Backer G
Department of Public Health, University Gent, Belgium.
Eur Heart J. 1996 Dec;17(12):1808-13. doi: 10.1093/oxfordjournals.eurheartj.a014796.
The association between blood lipids, apolipoproteins, fibrinogen, life-style-related factors and lipoprotein(a) was assessed in a cohort of middle-aged men.
Male employees, working in local industry, were invited to participate in a health survey at their worksite. After exclusion of nine persons with prevalent diabetes and 14 subjects with a history of myocardial infarction or angina, data were available on 720 healthy Caucasian men.
Lipoprotein(a) concentration was measured using an enzyme-linked immunosorbent assay (ELISA), and distribution was found to be highly skewed with a median level of 9 mg.dl-1 (mean level 23.1 mg.dl-1). The percentage of subjects with lipoprotein(a) levels higher than 30 mg.dl-1 was 23.6%. Univariate analysis showed a significant association between lipoprotein(a) and age, total cholesterol, apolipoprotein B and fibrinogen. However, no relationship was found with body mass index, waist to hip ratio, smoking, blood pressure, alcohol consumption, diet, HDL cholesterol, apolipoprotein AI and apolipoprotein E concentration or apolipoprotein E polymorphism. In multivariate analysis, In-transformed lipoprotein(a) correlated positively with apolipoprotein B (P < 0.0001) and fibrinogen (P = 0.004). Proportional changes in lipoprotein(a) concentration were predicted in relation to specified changes in biochemical and lifestyle variables. A 20 mg.dl-1 increase in apolipoprotein B and a 75 mg.dl-1 increase in fibrinogen levels were estimated to increase lipoprotein(a) concentration by 29.4% and 21.5% respectively.
Our data confirm the existence of an independent association between lipoprotein(a) and fibrinogen and give evidence for correlation with apolipoprotein B.
在一组中年男性队列中评估了血脂、载脂蛋白、纤维蛋白原、生活方式相关因素与脂蛋白(a)之间的关联。
邀请当地工业企业的男性员工在其工作地点参加健康调查。排除9名患有糖尿病的人和14名有心肌梗死或心绞痛病史的受试者后，获得了720名健康白种男性的数据。
采用酶联免疫吸附测定（ELISA）法测量脂蛋白(a)浓度，发现其分布高度偏态，中位数水平为9mg·dl⁻¹（平均水平23.1mg·dl⁻¹）。脂蛋白(a)水平高于30mg·dl⁻¹的受试者百分比为23.6%。单因素分析显示脂蛋白(a)与年龄、总胆固醇、载脂蛋白B和纤维蛋白原之间存在显著关联。然而，未发现与体重指数、腰臀比、吸烟、血压、饮酒、饮食、高密度脂蛋白胆固醇、载脂蛋白AI和载脂蛋白E浓度或载脂蛋白E多态性之间存在关系。在多因素分析中，经In转换的脂蛋白(a)与载脂蛋白B（P<0.0001）和纤维蛋白原（P=0.004）呈正相关。根据生化和生活方式变量的特定变化预测了脂蛋白(a)浓度的比例变化。载脂蛋白B增加20mg·dl⁻¹和纤维蛋白原水平增加75mg·dl⁻¹估计分别会使脂蛋白(a)浓度增加29.4%和21.5%。
我们的数据证实了脂蛋白(a)与纤维蛋白原之间存在独立关联，并为其与载脂蛋白B的相关性提供了证据。
