异基因骨髓移植后闭塞性细支气管炎伴机化性肺炎（BOOP）

[Bronchiolitis obliterans organizing pneumonia (BOOP) after allogeneic bone marrow transplantation].

作者信息

Nakayama M, Takahashi S, Inoue T, Nagamura F, Setoyama M, Ooi J, Takahashi T, Oshima Y, Miyamoto K, Uemura N, Shindo E, Tajika K, Yanagisawa K, Nagayama H, Okamoto S, Tojo A, Tani K, Ozawa K, Asano S, Wakabayashi T, Sato N, Ichinose Y, Toyama K, Saito H

机构信息

Department of Hematology/Oncology Institute of Medical Science, University of Tokyo.

出版信息

Rinsho Ketsueki. 1996 Nov;37(11):1271-5.

PMID:8960660

Abstract

We report a patient who underwent allogeneic bone marrow transplantation for ALL. The patient presented low grade fever, cough and dyspnea at day 3 after after bone marrow transplantation. Imaging studies showed bilateral patchy infiltrates on chest X-ray and chest CT. Though treated by antibiotics, chest auscultation recognized marked bilateral inspiratory crackles. Transbronchial lung biopsy performed on day 34 showed bronchiolitis obliterans and an organizing interstitial pneumonia. The patient was treated with methylprednisolone and follow up computed tomography findings improved.

摘要

我们报告了一名接受异基因骨髓移植治疗急性淋巴细胞白血病（ALL）的患者。该患者在骨髓移植后第3天出现低热、咳嗽和呼吸困难。影像学检查显示胸部X线和胸部CT有双侧斑片状浸润影。尽管使用了抗生素治疗，但胸部听诊仍可闻及明显的双侧吸气性啰音。在第34天行经支气管肺活检，结果显示闭塞性细支气管炎和机化性间质性肺炎。该患者接受了甲泼尼龙治疗，后续计算机断层扫描结果有所改善。