慢性铅中毒所致贫血

[Anemia due to chronic lead poisoning].

作者信息

Tanaka K, Sakamoto A, Shiraishi K, Tanaka M, Fukahori S, Mizunoe K, Masuchi K, Jojima H, Osabe S, Imamura Y, Honda J, Egami K, Natori H, Oizumi K

机构信息

First Department of Internal Medicine, Kurume University School of Medicine.

出版信息

Rinsho Ketsueki. 1996 Nov;37(11):1325-7.

PMID:8960671

Abstract

We report a case of anemia due to chronic lead poisoning. A 46-year-old female was admitted to our hospital because of general fatigue and anemia. A peripheral blood smear showed basophilic stippling. There was basophilic stippling and nuclear dysplasia of erythroblasts in the bone marrow. Laboratory findings were as follows: RBC 296 X 10(4)/microliter, Hb 8.5 g/dl, blood lead concentration 67 micrograms/dl, urinary lead concentration 309 micrograms/l, blood delta-ALA dehydrase 0.03 mumol/ml, urinary delta-ALA 25.2 mg/l, urinary coproporphyrin 8,810 micrograms/g.Cr, and blood protoporphyrin 612 micrograms/dl. Chronic lead poisoning was diagnosed and she was treated with Ca-EDTA.

摘要

我们报告一例因慢性铅中毒导致的贫血病例。一名46岁女性因全身乏力和贫血入住我院。外周血涂片显示嗜碱性点彩。骨髓中可见幼红细胞嗜碱性点彩和核发育异常。实验室检查结果如下：红细胞296×10⁴/微升，血红蛋白8.5克/分升，血铅浓度67微克/分升，尿铅浓度309微克/升，血δ-氨基乙酰丙酸脱水酶0.03微摩尔/毫升，尿δ-氨基乙酰丙酸25.2毫克/升，尿粪卟啉8810微克/克肌酐，血原卟啉612微克/分升。诊断为慢性铅中毒，给予依地酸钙钠治疗。