Yamamoto T, Kino T, Yagi K, Miyata H, Yoshioka K
Department of Pediatrics, Kinki University School of Medicine.
Rinsho Ketsueki. 1996 Nov;37(11):1328-30.
A case of acute thrombocytopenic purpura following rubella vaccination is reported. A 3-year-old boy developed purpura on the 22nd days after rubella vaccination. His platelet count was 34 x 10(3)/microliter. Platelet-associated IgG was elevated, but the amount of megakaryocytes in bone marrow aspirates was within the normal range, suggesting immune mechanism-associated thrombocytopenia. He recovered spontaneously within one month. Thrombocytopenic purpura is a well-documented complication of natural rubella infection. Attention should be paid rubella vaccination-associated thrombocytopenia, though it seems to be less frequent than after natural infections.
报告了1例风疹疫苗接种后发生急性血小板减少性紫癜的病例。一名3岁男孩在接种风疹疫苗后第22天出现紫癜。他的血小板计数为34×10³/微升。血小板相关IgG升高,但骨髓穿刺液中巨核细胞数量在正常范围内,提示免疫机制相关的血小板减少。他在1个月内自发康复。血小板减少性紫癜是自然风疹感染的一种有充分记录的并发症。尽管风疹疫苗接种相关的血小板减少似乎比自然感染后少见,但仍应予以关注。