Oksaranta O, Tarvonen S, Ilonen J, Poikonen K, Reunanen M, Panelius M, Salonen R
Turku Immunology Centre, Finland.
Neurology. 1996 Dec;47(6):1542-5. doi: 10.1212/wnl.47.6.1542.
We analyzed the relative and absolute numbers of CD4+ cells positive and negative for CD45RA marker as well as the numbers of CD8+ cells positive and negative for CD11b in the cerebrospinal fluid (CSF) and peripheral blood (PB) of 17 patients with multiple sclerosis (MS) during and 60 days after an exacerbation. We also studied samples from 27 control patients, 17 of whom had a noninflammatory neurologic disease and 10 of whom had an inflammatory neurologic disease other than MS. The results confirmed the small number of CD45RA-positive (naive or suppressor inducer) CD4+ cells as well as CD11b-positive (suppressor) CD8+ cells in the CSF compared with the PB for all paired CSF-blood comparisons. The relative numbers of these cells did not significantly differ between samples taken during an exacerbation and those taken 2 months later. In PB, the percentage of CD8+ CD11b-positive lymphocytes was lower in patients with MS or in patients with an inflammatory neurologic disease than in patients with a noninflammatory neurologic disease. The results indicate that there are fewer cells responsible for suppression-related phenomena in CSF than in PB but that this phenomenon is not specific to MS.
我们分析了17例多发性硬化症（MS）患者病情加重期间及加重后60天，其脑脊液（CSF）和外周血（PB）中CD45RA标记阳性和阴性的CD4 +细胞的相对数量和绝对数量，以及CD11b阳性和阴性的CD8 +细胞的数量。我们还研究了27例对照患者的样本，其中17例患有非炎性神经系统疾病，10例患有除MS以外的炎性神经系统疾病。结果证实，在所有配对的脑脊液 - 血液比较中，与外周血相比，脑脊液中CD45RA阳性（初始或抑制诱导）CD4 +细胞以及CD11b阳性（抑制）CD8 +细胞数量较少。这些细胞的相对数量在病情加重期间采集的样本与2个月后采集的样本之间没有显著差异。在外周血中，MS患者或炎性神经系统疾病患者的CD8 + CD11b阳性淋巴细胞百分比低于非炎性神经系统疾病患者。结果表明，脑脊液中负责抑制相关现象的细胞比外周血中的少，但这种现象并非MS所特有。
