Nyengaard J R, Bendtsen T F, Mogensen C E
Stereological Research Laboratory, Aarhus University, Denmark.
Diabetologia. 1996 Dec;39(12):1634-7. doi: 10.1007/s001250050627.
These studies were undertaken to ascertain if there is any association between low birth weight, and low kidney weight, few and/or small glomeruli, in kidneys from a control group and a group of non-insulin-dependent diabetic (NIDDM) patients. The background for this study comes from findings suggesting a correlation between low birth weight and the development of NIDDM and high blood pressure. Furthermore, Brenner has postulated that humans born with a low number of glomeruli, thereby having a low glomerular filtration surface area, have a greater tendency to develop high blood pressure. We examined 79 autopsy kidneys, with known weight from normal and NIDDM patients, which had previously been used for studies of glomerular number and volume. In the archives of the Danish midwives we were able to find birth weight for 26 NIDDM patients and an age- and sex-matched sample of 19 control persons. The kidney weight (g) (
137 +/- 36; NIDDM: 150 +/- 38; 2p = 0.26), glomerular number (10(3)) (CONTROL: 670 +/- 176; NIDDM: 673 +/- 200; 2p = 0.95), glomerular volume (10(6) micron3) (CONTROL: 6.25 +/- 1.48; NIDDM: 5.71 +/- 1.74; 2p = 0.28) or birth weight (g) (
3577 +/- 400; NIDDM: 3489 +/- 429; 2p = 0.49) were not different between the groups. There was no significant correlation between birth weight and glomerular number (
2p = 0.80; r = 0.06 and NIDDM: 2p = 0.10; r = -0.33), glomerular volume (
2p = 0.43; r = 0.19 and NIDDM: 2p = 0.78; r = 0.06) or kidney weight (
2p = 0.56; r = 0.14 and NIDDM: 2p = 0.81; r = 0.05). Our results on a limited number of subjects in Denmark do not support the hypothesis that there is any association between low birth weight and low kidney weight or low birth weight and few and/or small glomeruli in NIDDM patients.
开展这些研究是为了确定在对照组和非胰岛素依赖型糖尿病（NIDDM）患者组的肾脏中，低出生体重与低肾重、肾小球数量少和/或体积小之间是否存在任何关联。这项研究的背景源于一些研究结果，这些结果表明低出生体重与NIDDM及高血压的发生之间存在关联。此外，布伦纳推测，出生时肾小球数量少、因而肾小球滤过表面积小的人，患高血压的倾向更大。我们检查了79个尸检肾脏，这些肾脏来自正常人和NIDDM患者，其重量已知，之前已用于肾小球数量和体积的研究。在丹麦助产士的档案中，我们找到了26名NIDDM患者的出生体重以及19名年龄和性别匹配的对照者的样本。两组之间的肾重（克）（对照组：137±36；NIDDM组：150±38；P=0.26）、肾小球数量（10³）（对照组：670±176；NIDDM组：673±200；P=0.95）、肾小球体积（10⁶立方微米）（对照组：6.25±1.48；NIDDM组：5.71±1.74；P=0.28）或出生体重（克）（对照组：3577±400；NIDDM组：3489±429；P=0.49）并无差异。出生体重与肾小球数量（对照组：P=0.80；r=0.06；NIDDM组：P=0.10；r=-0.33）、肾小球体积（对照组：P=0.43；r=0.19；NIDDM组：P=0.78；r=0.06）或肾重（对照组：P=0.56；r=0.14；NIDDM组：P=0.81；r=0.05）之间均无显著相关性。我们在丹麦对有限数量受试者的研究结果不支持低出生体重与NIDDM患者低肾重或低出生体重与肾小球数量少和/或体积小之间存在任何关联这一假设。
