Silva J M, Souza I, Silva R, Tavares P, Teixeira F, Silva P S
2nd Department of Internal Medicine, University Hospital of Coimbra, Portugal.
Int J Cardiol. 1996 Nov 15;57(1):75-80. doi: 10.1016/s0167-5273(96)02810-0.
We investigated the efficacy of fish oils in Portuguese patients with hypertriglyceridaemia and mixed hyperlipidaemia, and the influence of fish consumption on the triglyceride lowering capacity of fish oils. Forty patients participated in this double-blind study, consisting of a 4-week dietary or wash-out baseline period after which patients were randomly assigned to receive either 12 fish oil capsules (3.6 g/day of omega 3) or similar 12 soya oil capsules per day for a period of 2 months. There were no statistically significant changes of total, HDL or LDL-cholesterol, and triglycerides. Nevertheless, triglycerides increased 19.9% with soya oil and decreased 27.8% with fish oils. Also, there was an inverse relationship (rho = -0.352) between fish consumption and fish oils effect on triglycerides, and the triglyceride lowering with fish oils increased (from 27.8% to 44.4%), reaching borderline significance, if we excluded patients consuming one or more meals with fish per day. Glucose increased 11% (P = 0.0047) with fish oils. These findings suggest that the triglyceride lowering effect of fish oils is affected by fish consumption, and confirm that fish oils increase blood glucose levels in diabetics and non-diabetics.
我们研究了鱼油对葡萄牙高甘油三酯血症和混合型高脂血症患者的疗效，以及鱼类摄入对鱼油降低甘油三酯能力的影响。40名患者参与了这项双盲研究，研究包括为期4周的饮食或洗脱基线期，之后患者被随机分配，每天服用12粒鱼油胶囊（3.6克/天的ω-3）或类似的12粒大豆油胶囊，为期2个月。总胆固醇、高密度脂蛋白或低密度脂蛋白胆固醇以及甘油三酯均无统计学上的显著变化。然而，服用大豆油后甘油三酯升高了19.9%，服用鱼油后降低了27.8%。此外，鱼类摄入量与鱼油对甘油三酯的作用之间存在负相关关系（相关系数ρ = -0.352），如果我们排除每天食用一餐或多餐鱼类的患者，鱼油降低甘油三酯的幅度会增加（从27.8%增至44.4%），达到临界显著性水平。服用鱼油后血糖升高了11%（P = 0.0047）。这些发现表明，鱼油降低甘油三酯的效果受鱼类摄入量的影响，并证实鱼油会使糖尿病患者和非糖尿病患者的血糖水平升高。
