Itakura A, Kurauchi O, Hayakawa F, Matsuzawa K, Mizutani S, Tomoda Y
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
Int J Gynaecol Obstet. 1996 Nov;55(2):111-5. doi: 10.1016/s0020-7292(96)02741-5.
To estimate the timing of brain damage involved in the onset of periventricular leukomalacia in the perinatal period we recorded and analyzed neonatal electroencephalograms (EEGs).
Twenty-four preterm birth infants proved by real time ultrasonic examination or MRI to be suffering from periventricular leukomalacia underwent serial electroencephalography from soon after birth.
Thirteen (54%) demonstrated intrauterine injury patterns, 2 infants (8%) showed postnatal injury, and in the remaining 9 cases (38%) the time of injury could not be determined by electroencephalography. Antepartum maternal hemorrhage (6), premature rupture of membranes (3), twining (3), chorioamnionitis (2), and perinatal asphyxia (2) were complications encountered in the group with intrauterine injury patterns.
Our observations suggest that more than half of periventricular leukomalacia cases are associated with premature birth infants showing intrauterine injury patterns on electroencephalography, indicating the existence of intrauterine insult.
为了评估围生期脑室周围白质软化症发病过程中脑损伤的发生时间，我们记录并分析了新生儿脑电图（EEG）。
通过实时超声检查或磁共振成像（MRI）证实患有脑室周围白质软化症的24例早产婴儿在出生后不久接受了系列脑电图检查。
13例（54%）显示宫内损伤模式，2例婴儿（8%）表现为出生后损伤，其余9例（38%）损伤时间无法通过脑电图确定。宫内损伤模式组出现的并发症有产前母体出血（6例）、胎膜早破（3例）、双胎妊娠（3例）、绒毛膜羊膜炎（2例）和围生期窒息（2例）。
我们的观察结果表明，超过一半的脑室周围白质软化症病例与早产婴儿有关，这些婴儿脑电图显示宫内损伤模式，提示存在宫内损害。
