血栓调节蛋白、纤溶酶原激活物抑制剂1（PAI-1）和纤连蛋白作为子痫前期和子痫内皮损伤的生物标志物。
Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia.
作者信息
Shaarawy M, Didy H E
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt.
出版信息
Int J Gynaecol Obstet. 1996 Nov;55(2):135-9. doi: 10.1016/s0020-7292(96)02755-5.
OBJECTIVE
Preeclampsia has been recently suggested to be an endothelial cell disorder. This study was initiated to determine the levels of various biomarkers of endothelial damage in preeclampsia and eclampsia.
METHODS
Blood samples were withdrawn from 70 pregnant women in their third trimester grouped as 25 mild preeclampsia, 15 severe preeclampsia, 10 eclampsia and 20 normotensive healthy women (controls) for the determination of thrombomodulin by ELISA, PAI-1 by urokinase method and fibronectin by radial immunodiffusion. Results were statistically analyzed by Student's t-test.
RESULTS
Circulation levels of PAI-1, thrombomodulin and fibronectin were increased with increasing severity of the disease. Thrombomodulin was the only parameter which did not change significantly in mild preeclampsia. The average percent increments in preeclampsia and eclampsia were 63%, 102% and 132%, respectively.
CONCLUSIONS
These results demonstrate that fibronectin may be a more valuable biomarker than thrombomodulin and PAI-1 for the assessment of endothelial damage in preeclampsia and eclampsia.
目的
最近有研究表明子痫前期是一种内皮细胞紊乱疾病。本研究旨在确定子痫前期和子痫患者内皮损伤的各种生物标志物水平。
方法
采集70例孕晚期孕妇的血样，分为25例轻度子痫前期、15例重度子痫前期、10例子痫患者和20例血压正常的健康孕妇（对照组），采用酶联免疫吸附测定法检测血栓调节蛋白，采用尿激酶法检测纤溶酶原激活物抑制剂-1（PAI-1），采用放射免疫扩散法检测纤连蛋白。结果采用学生t检验进行统计学分析。
结果
随着疾病严重程度的增加，PAI-1、血栓调节蛋白和纤连蛋白的循环水平升高。血栓调节蛋白是轻度子痫前期唯一未显著变化的参数。子痫前期和子痫患者的平均增加百分比分别为63%、102%和132%。
结论
这些结果表明，对于评估子痫前期和子痫患者的内皮损伤，纤连蛋白可能是比血栓调节蛋白和PAI-1更有价值的生物标志物。
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