Schwan W R, Kopecko D J
Laboratory of Enteric and Sexually Transmitted Diseases, Food and Drug Administration-Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA.
FEMS Microbiol Lett. 1996 Dec 1;145(2):215-9. doi: 10.1111/j.1574-6968.1996.tb08580.x.
Uptake of Salmonella typhimurium into murine macrophage cells caused transcriptional downregulation of a mRNA population in eukaryotic cells after 2 h of infection. The cloned cDNA that was identified showed extensive homology with a murine alpha 1,2-mannosidase gene involved in N-oligosaccharide processing. These findings suggest a disruption of eukaryotic protein processing after phagocytosis of S. typhimurium by the murine macrophage cells.
鼠伤寒沙门氏菌进入小鼠巨噬细胞后，在感染2小时后导致真核细胞中一个mRNA群体的转录下调。所鉴定出的克隆cDNA与一个参与N-寡糖加工的小鼠α1,2-甘露糖苷酶基因具有广泛的同源性。这些发现表明，鼠巨噬细胞吞噬鼠伤寒沙门氏菌后，真核蛋白质加工受到破坏。
