鼠伤寒沙门氏菌被鼠巨噬细胞摄取后小鼠高尔基体甘露糖苷酶基因的转录下调。
Transcriptional downregulation of a mouse Golgi mannosidase gene following Salmonella typhimurium uptake into murine macrophages.
作者信息
Schwan W R, Kopecko D J
机构信息
Laboratory of Enteric and Sexually Transmitted Diseases, Food and Drug Administration-Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA.
出版信息
FEMS Microbiol Lett. 1996 Dec 1;145(2):215-9. doi: 10.1111/j.1574-6968.1996.tb08580.x.
Uptake of Salmonella typhimurium into murine macrophage cells caused transcriptional downregulation of a mRNA population in eukaryotic cells after 2 h of infection. The cloned cDNA that was identified showed extensive homology with a murine alpha 1,2-mannosidase gene involved in N-oligosaccharide processing. These findings suggest a disruption of eukaryotic protein processing after phagocytosis of S. typhimurium by the murine macrophage cells.
鼠伤寒沙门氏菌进入小鼠巨噬细胞后，在感染2小时后导致真核细胞中一个mRNA群体的转录下调。所鉴定出的克隆cDNA与一个参与N-寡糖加工的小鼠α1,2-甘露糖苷酶基因具有广泛的同源性。这些发现表明，鼠巨噬细胞吞噬鼠伤寒沙门氏菌后，真核蛋白质加工受到破坏。
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