Clementz B A
Department of Psychology, University of California-San Diego, La Jolla, USA.
Psychophysiology. 1996 Nov;33(6):650-4. doi: 10.1111/j.1469-8986.1996.tb02360.x.
People diagnosed with schizophrenia have abnormalities of smooth pursuit eye movement initiation that could be attributable to dysfunction of posterior cortical areas and/or the smooth pursuit regions of frontal cortex. To evaluate whether schizophrenia patients' pursuit initiation performance is most consistent with pre- or postrolandic neuropathology, 25 schizophrenia patients and 25 nonpsychiatric individuals were presented step-ramp stimuli moving either away from or toward the fovea. Schizophrenia and nonpsychiatric individuals did not differ on position error of saccades to moving targets, suggesting that the schizophrenia patients did not have general difficulty with motion perception. During the initial 100 ms of smooth pursuit, however, schizophrenia patients had significantly slower eye velocities than did nonpsychiatric individuals. These results suggest that schizophrenia patients' smooth pursuit abnormalities are not associated with neuropathology of posterior cortical areas.
被诊断为精神分裂症的患者存在平滑追踪眼球运动起始异常，这可能归因于后皮质区域和/或额叶皮质平滑追踪区域的功能障碍。为了评估精神分裂症患者的追踪起始表现与罗兰德前或罗兰德后神经病理学是否最为一致，对25名精神分裂症患者和25名非精神疾病个体呈现了远离或朝向中央凹移动的阶梯斜坡刺激。精神分裂症患者和非精神疾病个体在对移动目标的扫视位置误差上没有差异，这表明精神分裂症患者在运动感知方面没有普遍困难。然而，在平滑追踪的最初100毫秒内，精神分裂症患者的眼球速度明显慢于非精神疾病个体。这些结果表明，精神分裂症患者的平滑追踪异常与后皮质区域的神经病理学无关。
