甘丙肽及甘丙肽受体在大鼠胚胎多种感觉系统和骨原基中的表达
Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos.
作者信息
Xu Z Q, Shi T J, Hökfelt T
机构信息
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
出版信息
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14901-5. doi: 10.1073/pnas.93.25.14901.
Abstract
Using in situ hybridization and immunohistochemistry the expression of, respectively, prepro-galanin (pre-pro-GAL) mRNA and GAL receptor-1 mRNA, as well as GAL-like and GAL message-associated peptide-like immunoreactivities, were studied in rats from embryonic day 14 (E14) to postnatal day 1. GAL expression was observed already at E14 in trigeminal and dorsal root ganglion neurons and at E15 in the sensory epithelia in developing ear, eye, and nose, as well as at E19 during bone formation. Also, GAL receptor-1 mRNA was expressed in the sensory ganglia of embryos but appeared later than the ligand. These findings suggest that GAL and/or GAL message-associated peptide may have a developmental role in several sensory systems and during bone formation.
摘要
运用原位杂交和免疫组织化学技术，分别研究了从胚胎第14天（E14）至出生后第1天的大鼠中前甘丙肽原（pre-pro-GAL）mRNA和甘丙肽受体-1 mRNA的表达，以及甘丙肽样和甘丙肽信息相关肽样免疫反应性。在E14时，三叉神经节和背根神经节神经元中已观察到甘丙肽表达；在E15时，发育中的耳、眼和鼻的感觉上皮中也有表达，并且在E19骨形成过程中也有表达。此外，甘丙肽受体-1 mRNA在胚胎感觉神经节中表达，但出现时间晚于配体。这些发现表明，甘丙肽和/或甘丙肽信息相关肽可能在多个感觉系统以及骨形成过程中发挥发育作用。
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