[低血液酒精浓度下的视觉诱发电位]
[Visual evoked potentials in low blood alcohol concentrations].
作者信息
Behrendt S, Kaatsch H J, Schwinger R
机构信息
Klinik für Ophthalmologie, Christian-Albrechts-Universität, Kiel.
出版信息
Ophthalmologe. 1996 Aug;93(4):367-70.
BACKGROUND
Both the acute toxic effects of ethanol on the central nervous system and the effects of chronic alcohol consumption on the optic nerve (tobacco-alcohol amblyopia) are well known. We investigated the acute effect of low blood alcohol concentrations on visual evoked potentials.
MATERIALS AND METHODS
A pattern VEP (stimulation by TV monitor, alternating chequerboard patterns, 45', 2 Hz, contrast 90%) was performed in ten healthy volunteers in sober condition and 0, 30, 60, 90 and 120 min following ingestion of 1 g/kg body weight ethanol (resulting in a blood alcohol concentration of 0.8-1.1%). Blood samples were drawn from the cubital vein simultaneously with each recording to determine blood alcohol concentration.
RESULTS
Neither peak latencies nor amplitudes showed significant changes related to blood alcohol concentration.
CONCLUSION
No acute impairment of the optic nerve caused by ingestion of low doses of alcohol could be found using pattern VEP.
背景
乙醇对中枢神经系统的急性毒性作用以及长期饮酒对视神经的影响（烟酒性弱视）均已为人熟知。我们研究了低血酒精浓度对视觉诱发电位的急性影响。
材料与方法
对10名健康志愿者进行图形视觉诱发电位检测（通过电视监视器刺激，交替棋盘格图案，45'，2Hz，对比度90%），检测时间分别为清醒状态以及摄入1g/kg体重乙醇后0、30、60、90和120分钟（血酒精浓度达0.8 - 1.1%）。每次记录时同时从肘静脉采集血样以测定血酒精浓度。
结果
峰潜伏期和波幅均未显示出与血酒精浓度相关的显著变化。
结论
使用图形视觉诱发电位未发现低剂量酒精摄入引起视神经的急性损伤。
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