Rudakovskii M L, Buravkova L B, Pavlov B N
State Scientific Center RF "Institute of Medical-Biological Problems".
Aviakosm Ekolog Med. 1996;30(1):51-4.
With the use of Ussing unit adapted for the hyperbaric environment it is demonstrated that an increase of hydrostatic pressure to 20 MPa results in hyperpolarization of the isolated abdominal skin of the frog (in average 6.5 %/MPa). Further increase of pressure in the range from 25 to 35 MPa produces the stabilization of the recorded parameter. At a pressure higher than 35 MPa there occurs the sharp decrease in transcutaneous difference of the potentials. The involvement and role of the active and passive ionic currents in the effects of high pressure on the membrane transport processes and the capabilities of the applied biological model for studying the effect of hyperbaric environment to the living systems are discussed.
使用适用于高压环境的尤斯灌流室装置，结果表明，将静水压力增加至20兆帕会导致青蛙离体腹部皮肤超极化（平均为6.5%/兆帕）。压力在25至35兆帕范围内进一步升高会使记录参数稳定。当压力高于35兆帕时，经皮电位差会急剧下降。本文讨论了主动和被动离子电流在高压对膜转运过程影响中的作用，以及所应用的生物学模型在研究高压环境对生命系统影响方面的能力。
