[Effect of high hydrostatic pressure on spontaneously generated difference of the potentials of isolated skin of the frog].

With the use of Ussing unit adapted for the hyperbaric environment it is demonstrated that an increase of hydrostatic pressure to 20 MPa results in hyperpolarization of the isolated abdominal skin of the frog (in average 6.5 %/MPa). Further increase of pressure in the range from 25 to 35 MPa produces the stabilization of the recorded parameter. At a pressure higher than 35 MPa there occurs the sharp decrease in transcutaneous difference of the potentials. The involvement and role of the active and passive ionic currents in the effects of high pressure on the membrane transport processes and the capabilities of the applied biological model for studying the effect of hyperbaric environment to the living systems are discussed.