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[产前应激对雄性大鼠垂体促性腺功能发育的影响]

[The effect of prenatal stress on the development of hypophyseal gonadotropic function in male rats].

作者信息

Tarasenko L V, Sinitsyn P V, Reznikov A G

出版信息

Fiziol Zh Im I M Sechenova. 1996 Apr;82(4):39-45.

PMID:8963337
Abstract

Significant changes of the aromatase and 5 alpha-reductase hypothalamic activity were found in juvenile prenatally stressed male Wistar rats. The blood plasma testosterone level increased following niftolide (NF) or 1, 4, 6-androstatine-3, 17-dione (ATD) administration. Prenatal stress seems to exert a modifying effect upon the regulating mechanisms of the pituitary gonadotropin function, lowering the functional reserves of the hypothalamo-hypophyseal-testicular axis in pre- and postpubertal male rats.

摘要

在幼年时受到产前应激的雄性Wistar大鼠中,发现芳香化酶和5α-还原酶的下丘脑活性有显著变化。给予尼氟灭酸(NF)或1,4,6-雄甾三烯-3,17-二酮(ATD)后,血浆睾酮水平升高。产前应激似乎对垂体促性腺激素功能的调节机制产生了修饰作用,降低了青春期前和青春期后雄性大鼠下丘脑-垂体-睾丸轴的功能储备。

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