Takase K, Nakano T, Hamada M, Shiraki K, Oohashi Y, Kihira T, Tameda Y
First Department of Internal Medicine, Mie University School of Medicine, Japan.
J Gastroenterol. 1995 Dec;30(6):795-7. doi: 10.1007/BF02349651.
A 30-year-old female with chronic hepatitis C treated with recombinant alpha-interferon developed serious hemolytic anemia after receiving 10 million units a day for 4 weeks. The results of Coombs' tests were negative before and after interferon therapy. The hemolytic anemia gradually improved after the withdrawal of recombinant alpha-interferon and the administration of methyl-prednisolone. The clinical course suggested that the recombinant alpha-interferon had provoked the hemolytic anemia.
一名30岁的慢性丙型肝炎女性患者，接受重组α干扰素治疗，每天1000万单位，治疗4周后出现严重溶血性贫血。干扰素治疗前后库姆斯试验结果均为阴性。停用重组α干扰素并给予甲泼尼龙后，溶血性贫血逐渐改善。临床病程提示重组α干扰素引发了溶血性贫血。
