[使用博利康尼进行宫缩抑制后脐血中的肌钙蛋白T水平]

[Troponin T levels in cord blood after tocolysis with Bricanyl].

作者信息

Adamcová M, Kokstein Z, Palicka V, Podholová M, Kost'ál M

机构信息

Katedra fyziologie LF UK, Hradec Králové.

出版信息

Ceska Gynekol. 1996 Aug;61(4):210-4.

PMID:8963487

Abstract

The present study was designed to evaluate the side-effects of preventive tocolysis by Bricanyl on the foetal myocardium using the new serological marker of myocardial damage-troponin T (TnT). The cardiac troponin T concentration was measured by means of commercial kits (Enzymun-Test System, Boehringer Mannheim, Germany) in the cord blood of 15 neonates. TnT serum concentration of neonates exposed in utero to Bricanyl was not significantly higher (mean 0.12 +/- 0.20 microgram/l) in comparison with the normal cardiac troponin T level but 4 of 15 neonates had an elevated TnT concentration (above 0.1 microgram/l). No correlation was found between TnT and CK or CK-MB.

摘要

本研究旨在使用心肌损伤的新血清学标志物——肌钙蛋白T（TnT），评估布瑞康诺预防性宫缩抑制对胎儿心肌的副作用。采用商用试剂盒（德国勃林格殷格翰公司的酶免疫检测系统）测定了15例新生儿脐带血中的心肌肌钙蛋白T浓度。与正常心肌肌钙蛋白T水平相比，宫内暴露于布瑞康诺的新生儿的TnT血清浓度无显著升高（平均0.12±0.20微克/升），但15例新生儿中有4例TnT浓度升高（高于0.1微克/升）。未发现TnT与CK或CK-MB之间存在相关性。