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The prolonged survival of human eosinophils with interleukin-5 and its inhibition by theophylline via apoptosis.

作者信息

Ohta K, Sawamoto S, Nakajima M, Kubota S, Tanaka Y, Miyasaka T, Nagai A, Hirai K, Mano K, Miyashita H

机构信息

Second Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

Clin Exp Allergy. 1996 Mar;26 Suppl 2:10-5. doi: 10.1111/j.1365-2222.1996.tb01137.x.

DOI:10.1111/j.1365-2222.1996.tb01137.x
PMID:8963870
Abstract
摘要

相似文献

1
The prolonged survival of human eosinophils with interleukin-5 and its inhibition by theophylline via apoptosis.
Clin Exp Allergy. 1996 Mar;26 Suppl 2:10-5. doi: 10.1111/j.1365-2222.1996.tb01137.x.
2
Eosinophil apoptosis caused by theophylline, glucocorticoids, and macrolides after stimulation with IL-5.白细胞介素-5刺激后，茶碱、糖皮质激素和大环内酯类药物引起的嗜酸性粒细胞凋亡。
J Allergy Clin Immunol. 1996 Dec;98(6 Pt 2):S207-15. doi: 10.1016/s0091-6749(96)70068-4.
3
Suppressive effect of tranilast on interleukin-5 prolonged eosinophils survival via apoptosis.曲尼司特通过凋亡对白细胞介素-5延长嗜酸性粒细胞存活的抑制作用。
Jpn J Pharmacol. 2001 May;86(1):130-3. doi: 10.1254/jjp.86.130.
4
The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil.Bcl-2表达的下调是茶碱诱导嗜酸性粒细胞凋亡所必需的。
Cell Immunol. 2000 Aug 1;203(2):95-102. doi: 10.1006/cimm.2000.1678.
5
Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.茶碱并非通过抑制磷酸二酯酶来加速人类粒细胞凋亡。
J Clin Invest. 1997 Oct 1;100(7):1677-84. doi: 10.1172/JCI119692.
6
Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils.白细胞介素-5抑制糖皮质激素介导的人嗜酸性粒细胞凋亡。
Thorax. 2010 Dec;65(12):1116-7. doi: 10.1136/thx.2009.124909. Epub 2010 Aug 30.
7
Transforming growth factor beta abrogates the effects of hematopoietins on eosinophils and induces their apoptosis.转化生长因子β消除造血生长因子对嗜酸性粒细胞的作用并诱导其凋亡。
J Exp Med. 1994 Mar 1;179(3):1041-5. doi: 10.1084/jem.179.3.1041.
8
Theophylline inhibits the release of eosinophil survival cytokines--is Raf-1 the protein kinase A target?
Clin Exp Allergy. 1998 Aug;28 Suppl 3:47-52.
9
Eosinophil resistance to glucocorticoid-induced apoptosis is mediated by the transcription factor NFIL3.嗜酸性粒细胞对糖皮质激素诱导的细胞凋亡的抗性是由转录因子NFIL3介导的。
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Ketotifen induces primary necrosis of human eosinophils.
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1
Concurrent oral and inhalation drug delivery using a dual formulation system: the use of oral theophylline carrier with combined inhalable budesonide and terbutaline.采用双配方系统同时进行口服和吸入式药物传递：使用口服茶碱载体与可吸入布地奈德和特布他林联合。
Drug Deliv Transl Res. 2014 Jun;4(3):256-67. doi: 10.1007/s13346-013-0137-z.
2
Eosinophil apoptosis and clearance in asthma.哮喘中嗜酸性粒细胞的凋亡与清除
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Treatment of apnea of prematurity.早产儿呼吸暂停的治疗。
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A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.茶碱的分子作用机制：诱导组蛋白脱乙酰酶活性以降低炎症基因表达。
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. doi: 10.1073/pnas.132556899. Epub 2002 Jun 17.
5
Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?磷酸二酯酶4抑制剂与哮喘治疗：我们目前的状况及未来走向？
Drugs. 2000 Feb;59(2):193-212. doi: 10.2165/00003495-200059020-00004.
6
Anti-oxidative effects of theophylline on human neutrophils involve cyclic nucleotides and protein kinase A.茶碱对人中性粒细胞的抗氧化作用涉及环核苷酸和蛋白激酶A。
Inflammation. 1998 Dec;22(6):545-57. doi: 10.1023/a:1022306328960.