Ruschitzka F, Schulz E, Kling H, Schrader J, Rath W
Abteilung Nephrologie und Rheumatologie, Medizinische Universitätsklinik, Göttingen.
Z Geburtshilfe Neonatol. 1996 May-Jun;200(3):100-3.
Ante- and postpartum noninvasive 24-hour ambulatory blood pressure measurements were performed in 18 normotensive pregnants and 36 patients with mild (n = 16) or severe preeclampsia (n = 12) or HELLP-syndrome (n = 8). In contrast to normotensive pregnancy (n = 18) displaying a decline of systolic and diastolic blood pressure in comparison with normotensive non-pregnant, preeclamptic women demonstrate significantly elevated blood pressure profiles before delivery that remain elevated up to the eighth week postpartum. 9 out of 12 patients with severe preeclampsia and 6 of 8 women with HELLP-syndrome show a nocturnal increase of blood pressure within the first week postpartum and a non-dipping up to the eighth week after delivery. As a result of this, in preeclamptic women blood pressure control should be extended into the night and antihypertensive therapy should include a sufficient evening dose.
对18名血压正常的孕妇以及36名患有轻度子痫前期（16例）、重度子痫前期（12例）或HELLP综合征（8例）的患者进行了产前和产后24小时动态血压测量。与血压正常的非孕期相比，血压正常的孕期（18例）收缩压和舒张压下降，而子痫前期女性在分娩前血压显著升高，且一直持续到产后第八周。12例重度子痫前期患者中有9例，8例HELLP综合征女性中有6例在产后第一周夜间血压升高，并且在产后第八周血压仍无勺型变化。因此，对于子痫前期女性，血压控制应延长至夜间，抗高血压治疗应包括足够的夜间剂量。
