Oney T, Meyer-Sabellek W
Department of Obstetrics, Free University of Berlin, Germany.
J Hypertens Suppl. 1990 Dec;8(6):S77-81.
In normal pregnancy the circadian blood pressure rhythm is similar to that in the non-pregnant state, with the highest blood pressure values in the morning and the lowest at midnight. This rhythm is lost in patients with pre-eclampsia. Women with severe pre-eclampsia show a reversed circadian rhythm, with a nocturnal increase in blood pressure during the sleeping phase. Although the reasons for this nocturnal hypertension in severe pre-eclampsia are poorly understood, the results suggest that pre-eclamptic women are endangered by hypertensive emergencies, mostly at night. Therefore blood pressure measurement should be extended to the night, and antihypertensive treatment must be adapted to the demands of a reversed circadian rhythm in relevant subgroups of patients.
在正常妊娠中，昼夜血压节律与非妊娠状态相似，早晨血压值最高，午夜最低。子痫前期患者会失去这种节律。重度子痫前期女性表现出昼夜节律逆转，睡眠期血压夜间升高。虽然重度子痫前期夜间高血压的原因尚不清楚，但结果表明，子痫前期女性大多在夜间面临高血压急症的风险。因此，血压测量应扩展到夜间，并且在相关患者亚组中，抗高血压治疗必须适应昼夜节律逆转的需求。
