Fukuyama J, Miyazawa K, Hamano S, Ujiie A
Central Research Laboratories, Kissei Pharmaceutical Co. Ltd., Nagano, Japan.
Can J Physiol Pharmacol. 1996 Jan;74(1):80-4.
The aim of this study was to examine the effects of tranilast (anti-allergic drug) on proliferation, migration, and collagen synthesis in cultures of human vascular smooth muscle cells. Tranilast at 100 and 300 microM had several inhibitory effects. One is the effect on vascular smooth muscle cell proliferation induced by fetal bovine serum and platelet-derived growth factor (PDGF)-BB. Second is the effect on PDGF-BB-induced migration. Third is the effect on c-myc expression after PDGF-BB stimulation. Lastly, tranilast reduced the spontaneous collagen synthesis without reducing total protein synthesis. These results suggest that tranilast may prevent restenosis after percutaneous transluminal coronary angioplasty via the inhibitory effects on proliferation, migration, c-myc gene expression, and collagen synthesis of vascular smooth muscle cells.
本研究旨在探讨曲尼司特（一种抗过敏药物）对人血管平滑肌细胞培养物中增殖、迁移及胶原合成的影响。100微摩尔和300微摩尔的曲尼司特具有多种抑制作用。一是对胎牛血清和血小板衍生生长因子（PDGF）-BB诱导的血管平滑肌细胞增殖的影响。二是对PDGF-BB诱导的迁移的影响。三是对PDGF-BB刺激后c-myc表达的影响。最后，曲尼司特可降低自发性胶原合成，而不降低总蛋白合成。这些结果表明，曲尼司特可能通过对血管平滑肌细胞的增殖、迁移、c-myc基因表达及胶原合成的抑制作用来预防经皮腔内冠状动脉成形术后再狭窄。
