Veronezi-Gurwell A, Wittchow R J, Bottles K, Cohen M B
Department of Pathology, University of Iowa, Iowa City, USA.
Diagn Cytopathol. 1996 Mar;14(2):145-9. doi: 10.1002/(SICI)1097-0339(199603)14:2<145::AID-DC8>3.0.CO;2-I.
Villous adenoma of the ampulla of Vater is a rare but distinct pathologic entity. We studied seven brush cytology specimens from four patients with this unusual lesion all of whom had surgical pathologic confirmation and clinical follow-up. The distinguishing cytologic appearance includes the presence of slender, elongate columnar cells arranged singly or in small sheets and clusters. Long, thin, basally oriented nuclei occupy about one third of the cell and have fine, granular chromatin with one or more nucleoli. Although brushings of villous adenoma of the ampullary region may reveal a relatively benign but distinctive morphologic pattern, the aggressive nature of these lesions has been well documented, including those in our patients.
壶腹绒毛状腺瘤是一种罕见但独特的病理实体。我们研究了来自4例患有这种罕见病变患者的7份刷检细胞学标本，所有患者均有手术病理确诊及临床随访。其特征性的细胞学表现包括存在细长的柱状细胞，这些细胞单个或呈小片状及簇状排列。细长的、基部定向的细胞核约占细胞的三分之一，具有细腻的颗粒状染色质及一个或多个核仁。尽管壶腹区域绒毛状腺瘤的刷检可能显示出相对良性但独特的形态学模式，但这些病变的侵袭性本质已有充分记录，包括我们患者中的病变。
