Alejandro P M, Castañón González J A, Miranda Ruiz R, Edgar Echeverria R, Adriana Montãno M
Servicio de Oftalmología, Hospital de Especialidades Dr. Bernardo Sepúlveda Centro Médico Nacional Siglo XXI. IMSS.
Gac Med Mex. 1994 Jul-Aug;130(4):227-30.
Sixteen patients with acute optic neuritis were studied, and randomized into two groups of treatment. Group I was assigned to in hospital treatment with intravenous methylprednisolone 500 mg Q8 hours for 10 doses, followed by oral prednisone for two weeks and tapering doses thereafter. Group II was treated with oral prednisone one mg per kilogram of body weight for two weeks followed by tapering doses. All patients had examination of visual acuity, visual field at baseline and repeated on weeks two, four and sixteen. Two patients in group I were lost to follow up, and three patients (two in group I and one in group II) had previous established diagnosis of Multiple Sclerosis and the onset of acute optic neuritis was considered a recurrence of the disease. There was no statistical difference between the groups with regards to clinical outcome, visual acuity and visual field examination (p = 0.329) Fisher test.
对16例急性视神经炎患者进行了研究，并将其随机分为两组进行治疗。第一组患者住院接受静脉注射甲基泼尼松龙治疗，每8小时500毫克，共10剂，随后口服泼尼松两周，之后逐渐减量。第二组患者接受口服泼尼松治疗，每公斤体重1毫克，持续两周，之后逐渐减量。所有患者在基线时进行视力、视野检查，并在第2、4和16周重复检查。第一组有2例患者失访，3例患者（第一组2例，第二组1例）先前已确诊为多发性硬化症，急性视神经炎的发作被认为是该疾病的复发。两组在临床结果、视力和视野检查方面无统计学差异（p = 0.329）（Fisher检验）。
