Villarreal G M, Alcocer-Varela J, Llorente L
Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Tlalpan, México.
Immunol Lett. 1996 Jan;49(1-2):105-9. doi: 10.1016/0165-2478(95)02490-5.
Primary Sjögren's syndrome (PSS) is an autoimmune inflammatory disorder characterized by lymphocytic infiltration of exocrine glands, B cell hyperactivity and autoantibody production. The aim of this study was to determine the presence of IL-10 and IL-13 in this disease. We studied the IL-10 and IL-13 gene expression in vivo by peripheral blood mononuclear cells and minor salivary glands from PSS patients. We found a high expression of the IL-10 gene and its product by their peripheral blood mononuclear cells (PBMC) as well as by their salivary glands. Peripheral blood B cells and monocytes were responsible for 89% of total IL-10 secretion. IL-13 gene expression was not observed in PBMNC from either PSS patients or healthy controls, and was confined to PSS salivary glands. Our results suggest that IL-10 and IL-13 contribute to the pathogenesis of PSS and might explain the B cell abnormalities and the development of lymphoma observed in this autoimmune disease.
原发性干燥综合征（PSS）是一种自身免疫性炎症性疾病，其特征为外分泌腺淋巴细胞浸润、B细胞功能亢进和自身抗体产生。本研究的目的是确定该疾病中白细胞介素-10（IL-10）和白细胞介素-13（IL-13）的存在情况。我们通过PSS患者的外周血单个核细胞和小唾液腺研究了IL-10和IL-13的体内基因表达。我们发现，PSS患者外周血单个核细胞（PBMC）及其唾液腺中IL-10基因及其产物的表达均较高。外周血B细胞和单核细胞占IL-10总分泌量的89%。在PSS患者或健康对照者的外周血单个核细胞中均未观察到IL-13基因表达，其仅局限于PSS唾液腺。我们的结果表明，IL-10和IL-13参与了PSS的发病机制，可能解释了在这种自身免疫性疾病中观察到的B细胞异常和淋巴瘤的发生。
