Lehrman E A, Crothers D M
Nucleic Acids Res. 1977;4(5):1381-92. doi: 10.1093/nar/4.5.1381.
Equilibrium dialysis, relaxation kinetic, melting, and continuous variation mixing experiments on complexes of poly(dA) and poly(rU) demonstrate that ethidium induces conversion of a 1:1 mixture of these homopolymers (at one molar salt and 19 degrees C) from a three stranded to a two stranded helix. This is the first demonstration of a double helix of poly(dA)-poly(rU) in solution.
对聚(dA)和聚(rU)复合物进行的平衡透析、弛豫动力学、熔解及连续变化混合实验表明,溴化乙锭可诱导这些均聚物的1:1混合物(在1摩尔盐浓度和19摄氏度条件下)从三链螺旋转变为双链螺旋。这是溶液中聚(dA)-聚(rU)双螺旋的首次证明。