碘-123-BMIPP在犬心肌中的代谢与动力学
Metabolism and kinetics of iodine-123-BMIPP in canine myocardium.
作者信息
Fujibayashi Y, Nohara R, Hosokawa R, Okuda K, Yonekura Y, Tamaki N, Konishi J, Sasayama S, Yokoyama A
机构信息
Department of Genetic Biochemistry, Faculty of Medicine, Kyoto University, Japan.
出版信息
J Nucl Med. 1996 May;37(5):757-61.
UNLABELLED
The kinetics and metabolic fate of 123I-15-(p-iodophenyl)-3-(R,S)- methylpentadecanoic acid (BMIPP) in canine myocardium were studied in an open-chest dog model.
METHODS
After left anterior descending artery injection of BMIPP, blood samples were collected from the corresponding great coronary vein (V) and femoral artery (A). On the basis of the A-V radioactivity difference as well as the HPLC elution profile at various time points, myocardial extraction, retention and metabolism of BMIPP were evaluated.
RESULTS
BMIPP was instantly extracted from the plasma into the myocardium (74% of the injected dose) and was then retained (65.3%). Washout of the retained radioactivity was low (8.7%) and most of the washout was as alpha- and beta-oxidation metabolites (2.3 + 2.9 + 1.4%), with little loss of BMIPP itself (2.1 %).
CONCLUSION
BMIPP is suitable for static SPECT imaging of the myocardium, and its slow washout appears to be due to metabolism through alpha- and beta-oxidation.
未标记
在开胸犬模型中研究了123I-15-（对碘苯基）-3-（R，S）-甲基十五烷酸（BMIPP）在犬心肌中的动力学和代谢命运。
方法
向左前降支动脉注射BMIPP后，从相应的大冠状静脉（V）和股动脉（A）采集血样。根据不同时间点的动静脉放射性差异以及高效液相色谱洗脱曲线，评估BMIPP的心肌摄取、滞留和代谢情况。
结果
BMIPP立即从血浆中摄取到心肌中（占注射剂量的74%），然后滞留（65.3%）。滞留放射性的洗脱率较低（8.7%），大部分洗脱为α-和β-氧化代谢产物（2.3 + 2.9 + 1.4%），BMIPP本身损失很少（2.1%）。
结论
BMIPP适用于心肌静态单光子发射计算机断层扫描成像，其缓慢洗脱似乎是由于通过α-和β-氧化代谢所致。
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