Kigami Y, Yamamoto I, Ohnishi H, Miura H, Ohnaka Y, Ota T, Yuu I, Masuda K, Morita R
Department of Radiology, Shiga University of Medical Science, Japan.
J Nucl Med. 1996 May;37(5):815-8.
To understand age-related changes of whole-body and regional skeletal metabolism, it is important to investigate the mechanisms of age-related bone loss and to develop suitable treatments for it. Bone biopsies show metabolism of the particular site examined while biochemical markers for bone metabolism reflect total skeletal metabolism. Bone scintigraphy is a convenient and simple way to analyze whole-body and regional skeletal metabolism. We attempted to study and understand age-related changes in bone metabolism by quantifying the bone scan and correlating it with biochemical bone metabolic markers.
The whole-body skeletal uptake (WBSU) and tracer distribution pattern were studied in men and women by bone scintigraphy using 99mTc-hydroxy-methane-diphosphonate (HMDP). Bone scans were performed using a standard protocol and quantified by setting regions of interest (ROIs) on selected regions. WBSU and the skeletal distribution pattern were compared with simultaneously obtained serum biochemical markers.
WBSU showed an increase with age in both sexes, but in women, uptake in the head and legs increased more relatively than in the thoracic region, while in men no such tendency was observed. Increase of WBSU and relative increase of uptakes in the head demonstrated a weak correlation with the serum levels of alkaline phosphatase and type 1 collagen metabolites.
These results show an age-related increase of skeletal turnover and sex-dependent regional skeletal metabolism. The age-related changes seen in bone scintigrams might be a sign of progressive bone loss, reflecting changes in local bone metabolism.
为了解全身及局部骨骼代谢的年龄相关变化，研究年龄相关骨质流失的机制并开发合适的治疗方法很重要。骨活检显示所检查特定部位的代谢情况，而骨代谢生化标志物反映的是整个骨骼的代谢情况。骨闪烁扫描是分析全身及局部骨骼代谢的一种便捷且简单的方法。我们试图通过对骨扫描进行定量并将其与骨代谢生化标志物相关联，来研究和了解骨代谢的年龄相关变化。
使用99m锝-羟基甲叉二膦酸盐（HMDP）通过骨闪烁扫描研究男性和女性的全身骨骼摄取（WBSU）及示踪剂分布模式。骨扫描按照标准方案进行，并通过在选定区域设置感兴趣区（ROI）进行定量。将WBSU和骨骼分布模式与同时获得的血清生化标志物进行比较。
男女的WBSU均随年龄增加，但在女性中，头部和腿部的摄取相对增加幅度大于胸部区域，而在男性中未观察到这种趋势。WBSU的增加及头部摄取的相对增加与血清碱性磷酸酶和I型胶原代谢产物水平呈弱相关。
这些结果显示骨骼转换随年龄增加且存在性别依赖性的局部骨骼代谢。骨闪烁扫描中所见的年龄相关变化可能是进行性骨质流失的迹象，反映了局部骨代谢的变化。
