Saito H
First Department of Internal Medicine, Hirosaki University School of Medicine.
Nihon Rinsho. 1996 May;54(5):1421-4.
Sensitivity of immunochemical occult blood testing (IFOBT) for early colorectal cancer (CRC) calculated in known cases is reported to be around 50-60%. Sensitivities of IFOBT for cancer in the preclinical stage were reported based on findings of colonoscopy performed on all screenees. Of 5715 asymptomatic persons who underwent flexible sigmoidoscopy (FS), 13 cases of early cancer were found, within the reach of FS. Sensitivities were 53.8%, 76.9 and 84.6% for one-day test, two-day test and three-day test of IFOBT by immunochemical hemagglutination, respectively. While corresponding figure was only 15.4% for three-day Hemoccult test. Other reports indicated that sensitivity of IFOBT is around 30% for small lesions of early CRC less than 1 cm in diameter. IFOBT is much more sensitive in detecting early CRC than Hemoccult test but is poorly sensitive for tiny early CRC.
据报道，在已知病例中计算得出的免疫化学潜血检测（IFOBT）对早期结直肠癌（CRC）的敏感性约为50%-60%。IFOBT对临床前期癌症的敏感性是根据对所有筛查对象进行结肠镜检查的结果报告的。在5715名接受乙状结肠镜检查（FS）的无症状者中，发现了13例早期癌症，均在FS可及范围内。通过免疫化学血凝法进行的IFOBT一日检测、两日检测和三日检测的敏感性分别为53.8%、76.9%和84.6%。而三日潜血试验的相应数字仅为15.4%。其他报告表明，对于直径小于1厘米的早期CRC小病变，IFOBT的敏感性约为30%。IFOBT在检测早期CRC方面比潜血试验敏感得多，但对微小早期CRC的敏感性较差。
