Aoyagi K, Koufuji K, Kodama I, Ohta J, Takamiya H, Mizutani K, Takeda J, Shirouzu K
First Department of Surgery, Kurume University, School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1996 Sep;93(9):613-9.
The expression of c-erB-2 and nm23 genes product were investigated immunohistochemically in 108 resected cases of early gastric cancer. The expression rate of c-erB-2 was significantly higher in the cases of submucosal cancer or in the cases with lymph node metastasis. The expression rate of c-erB-2 was higher in the metastatic tumor than in the primary tumor. There was no significant correlation between the expression of nm23 and depth of invasion. The expression rate of nm23 was lower in the cases with lymph node metastasis than in the cases without lymph node metastasis. The expression could not be found in the metastatic tumor. These results suggest that there would be correlation between the expression of c-erB-2 and depth of invasion and lymph node metastasis, and the nm23 may suppress metastatic potential in early gastric cancer.
应用免疫组织化学方法对108例早期胃癌手术切除标本进行c-erB-2和nm23基因产物表达的研究。黏膜下癌或有淋巴结转移的病例中c-erB-2的表达率显著较高。转移瘤中c-erB-2的表达率高于原发瘤。nm23的表达与浸润深度之间无显著相关性。有淋巴结转移的病例中nm23的表达率低于无淋巴结转移的病例。转移瘤中未发现该表达。这些结果提示，c-erB-2的表达与浸润深度及淋巴结转移之间可能存在相关性，nm23可能抑制早期胃癌的转移潜能。
