Kawabata Y, Sakamoto S, Umino T, Fukushima K, Ohtomo K, Yamada H, Aoki T, Nakajima Y
Division of Pathology, Research Institute of Tuberculosis, Tokyo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Aug;34(8):878-84.
We examined patterns of growth of cancer cells in specimens of alveoli taken from 41 patients with squamous cell carcinoma (36 men and 5 women, mean age 65 years). For comparison, 8 samples from patients with small cell carcinoma (6 men and 2 women, mean age 64) and 71 samples from patients with adenocarcinoma (48 men and 23 women, mean age 62) were also studied. The samples were fixed in formalin, embedded in paraffin, and then subjected to immunostaining. Glandular structures composed of non-atypical cuboidal cells with negative p53 staining and scanty positive PCNA staining were found in 90% of the samples of squamous cell carcinoma. In small cell carcinoma, 25% of the samples had small numbers of no-atypical glandular structures. In adenocarcinoma, no non-atypical glandular structures were seen. Glandular structures were observed in the periphery of the cancerous tissue. Some of these non-atypical cells were attached to the alveolar basement membranes. We conclude that squamous cell carcinoma grows between the basement membrane and the alveolar epithelium, and leaves noncancerous epithelium with glandular structure.
我们研究了41例鳞状细胞癌患者（36名男性和5名女性，平均年龄65岁）肺泡标本中癌细胞的生长模式。作为对照，我们还研究了8例小细胞癌患者（6名男性和2名女性，平均年龄64岁）的样本以及71例腺癌患者（48名男性和23名女性，平均年龄62岁）的样本。样本用福尔马林固定，石蜡包埋，然后进行免疫染色。在90%的鳞状细胞癌样本中发现了由非典型立方体细胞组成的腺结构，这些细胞p53染色阴性，PCNA染色弱阳性。在小细胞癌中，25%的样本有少量非典型腺结构。在腺癌中，未观察到非典型腺结构。腺结构见于癌组织周边。其中一些非典型细胞附着于肺泡基底膜。我们得出结论，鳞状细胞癌在基底膜和肺泡上皮之间生长，并留下具有腺结构的非癌上皮。
