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[激光荧光光谱术在肺癌术中诊断及分期中的应用]

[Laser fluorescence spectroscopy in intraoperative diagnosis and staging of lung cancer].

作者信息

Uspenskiĭ L V, Kuzin M I, Ablitsov I A, Rybin V K, Loshchenov V B

出版信息

Khirurgiia (Mosk). 1996(3):31-3.

PMID:8965441
Abstract

67 patients with different kind of lung diseases have been evaluated by intraoperative laser spectroscopy. 49 of them had lung cancer and 18 patients had nonmalignant tumors, tuberculomas and chronic abscess. Helium-neon laser has been used to study spectral parameters of a normal lung tissue and lungs with malignant and benign tumors intraoperatively. It was found that intensity of autofluorescence will increase in cancer tissue. This phenomenon may be used for differential diagnosis of a lung cancer with benign tumors and chronic pulmonary diseases. It was also shown that autofluorescence of metastatic lymph nodes is higher compared to their hyperplasia. That may be used for rapid diagnosis of metastases in mediastinal lymph nodes and intraoperative staging of lung cancer.

摘要

67例患有不同类型肺部疾病的患者接受了术中激光光谱检查。其中49例患有肺癌,18例患有非恶性肿瘤、结核瘤和慢性脓肿。术中使用氦氖激光研究正常肺组织以及患有恶性和良性肿瘤的肺组织的光谱参数。结果发现癌组织中的自体荧光强度会增加。这一现象可用于肺癌与良性肿瘤及慢性肺部疾病的鉴别诊断。研究还表明,转移性淋巴结的自体荧光高于其增生组织。这可用于纵隔淋巴结转移的快速诊断及肺癌的术中分期。

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