Liubina L V, Ziablitskiĭ V M
Patol Fiziol Eksp Ter. 1996 Jul-Sep(3):32-4.
The purpose of this work was to examine the relationship between the antiaggregatory activity of the vascular wall and the metastatic spread of experimental tumors. Rats with the tumor "Myosarcoma-1" displayed, on the average, a 30% reduction in the antiaggregatory activity of the aortic wall. Three-week of the animals with a combination of the drugs dipyridamole (0.84 mg/kg per os), phytin (14 mg/kg per os), glutamic acid (28 mg/kg per os) restored the antiaggregatory properties of the vascular wall virtually up to the control values. The similar result was observed with cordarone (60 mg/kg intraperitoneally): the antiaggregatory properties of the vascular wall increased on the average by 50%. The metastatic spread of tumor cells in mice with Lewis carcinoma of the lung decreased on the average twice while treating them with these agents. The findings point to the fact that drug correction of the antiaggregatory activity of the vascular wall reduces the rate of metastatic spread.
这项工作的目的是研究血管壁的抗聚集活性与实验性肿瘤转移扩散之间的关系。患有“肌肉肉瘤 -1”肿瘤的大鼠，其主动脉壁的抗聚集活性平均降低了30%。给动物连续三周口服双嘧达莫（0.84毫克/千克）、植酸（14毫克/千克）、谷氨酸（28毫克/千克）的药物组合，实际上可使血管壁的抗聚集特性恢复至对照值。用可达龙（60毫克/千克腹腔注射）也观察到了类似结果：血管壁的抗聚集特性平均提高了50%。用这些药物治疗时，患有肺Lewis癌的小鼠体内肿瘤细胞的转移扩散平均减少了一半。这些发现表明，药物纠正血管壁的抗聚集活性可降低转移扩散的速率。
