Zhuzhovskiĭ Iu G, Kuznetsova L P, Sochilina E E, Dmitrieva E N, Gololobov Iu G, Bykovskaia E Iu
Zh Evol Biokhim Fiziol. 1996 Mar-Apr;32(2):212-6.
The action of some phosphonium betains on cholinesterases from different biological sources has been studied. It has been shown, that all studied betains are reversible inhibitors of cholinesterase hydrolysis of acetyltiocholine. Inhibiting action of these compounds on acetylcholinesterases is about ten times weaker that of the majority of known phosphonium salts, while their action on butyrylcholinesterases has no peculiarities. There were found certain differences for each betain compounds in their action on cholinesterases from different biological sources. These results may be used for detail classification of cholinesterases and allow to extend knowledge in comparative enzymology.
研究了某些鏻甜菜碱对来自不同生物来源的胆碱酯酶的作用。结果表明，所有研究的甜菜碱都是乙酰硫代胆碱胆碱酯酶水解的可逆抑制剂。这些化合物对乙酰胆碱酯酶的抑制作用比大多数已知的鏻盐弱约十倍，而它们对丁酰胆碱酯酶的作用则没有特殊性。发现每种甜菜碱化合物对来自不同生物来源的胆碱酯酶的作用存在一定差异。这些结果可用于胆碱酯酶的详细分类，并有助于扩展比较酶学方面的知识。
