Beck K A, Nelson W J
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305-5426, USA.
Am J Physiol. 1996 May;270(5 Pt 1):C1263-70. doi: 10.1152/ajpcell.1996.270.5.C1263.
Normal cell function is dependent on the existence of membrane compartments that have unique populations of membrane proteins. Sorting of membrane proteins forms the basis for the biogenesis of distinct membrane compartments. There are many examples of membrane protein-sorting events in cells, but the molecular machinery involved is poorly understood. We discuss characteristics of a putative membrane protein-sorting machine and show that the spectrin-based membrane skeleton conforms to these characteristics. The spectrin-based membrane skeleton is a submembranous, spatially limited, two-dimensional lattice that binds a subset of membrane proteins. These properties allow the membrane skeleton to facilitate the formation of distinct membrane domains and thus reveal its potential as a membrane protein-sorting machine.
正常细胞功能依赖于具有独特膜蛋白群体的膜区室的存在。膜蛋白的分选是不同膜区室生物发生的基础。细胞中存在许多膜蛋白分选事件的例子，但其中涉及的分子机制却知之甚少。我们讨论了一种假定的膜蛋白分选机器的特征，并表明基于血影蛋白的膜骨架符合这些特征。基于血影蛋白的膜骨架是一种膜下的、空间有限的二维晶格，它结合了一部分膜蛋白。这些特性使膜骨架能够促进不同膜结构域的形成，从而揭示了其作为膜蛋白分选机器的潜力。
