Nikolov A, Karag'ozov I, Novachkov V
Akush Ginekol (Sofiia). 1996;35(1-2):63-6.
A prospective study was carried out a State Institute Hospital "Maĭchin dom" aiming to estimate the efficacy of GnRH-agonist Nafarelin in treating patients with endometriosis. Nafarelin was used by 40 women with endometriosis. The drug was applied as a nasal spray according to a therapeutic scheme and regarding definite criteria. Every patient was followed while using the drug and the following sings were registered: occurrence of amenorrhea, clinical sings, side effects, the period of control lasting for a year after the end of the treatment. In 27 women a quick and long-lasting amenorrhoea was induced with standard doses of the drug, while other 13 needed higher dosage to achieve the same effect. Relief of complaints was registered on 35 women. Improved palpatory status was found in 23 patients. In 4 women the disappearance of endometriomas was confirmed by laparoscopy. The existing side-effects are dos to the appearing hypoestrogenemia. After treatment with Nafarelin, during the period of observation, 5 women got pregnant.
在“Maĭchin dom”国立研究所医院开展了一项前瞻性研究，旨在评估促性腺激素释放激素（GnRH）激动剂那法瑞林治疗子宫内膜异位症患者的疗效。40名子宫内膜异位症女性使用了那法瑞林。该药物按照治疗方案并依据明确标准以鼻喷雾剂形式使用。每位患者在用药期间均接受随访，并记录以下体征：闭经的发生情况、临床体征、副作用以及治疗结束后为期一年的对照期情况。27名女性使用标准剂量药物诱导出快速且持久的闭经，而另外13名女性则需要更高剂量才能达到相同效果。35名女性的症状得到缓解。23名患者触诊情况改善。4名女性经腹腔镜检查证实子宫内膜瘤消失。现有的副作用归因于出现的低雌激素血症。使用那法瑞林治疗后，在观察期间，5名女性怀孕。
