Ranzani G N
Dipartimento di Genetica e Microbiologia, Università degli Studi, Pavia, Italy.
Ann Ist Super Sanita. 1996;32(1):101-10.
The aim of this paper is to review the most frequent genetic alterations found in gastric carcinoma, and to focus on the main differences between intestinal and diffuse cancer types. Particular emphasis will be given to tumor suppressor genes, above all to p53. The role of normal and mutated p53 proteins has been studied in depth in a variety of cell types, and p53 alterations have been extensively analysed in many human tumors, including gastric cancer. Accordingly, the paper will report p53 data on this neoplasia, and consider these data in the light of various more general notions.
本文旨在综述胃癌中最常见的基因改变，并聚焦于肠型和弥漫型癌症类型之间的主要差异。将特别强调肿瘤抑制基因，尤其是p53。正常和突变型p53蛋白的作用已在多种细胞类型中进行了深入研究，并且p53改变已在包括胃癌在内的许多人类肿瘤中得到广泛分析。因此，本文将报告关于这种肿瘤的p53数据，并根据各种更普遍的概念来考量这些数据。
