[Stabilization of roseofungin by antioxidants].

Stabilization of roseofungin, a pentaene antibiotic, by antioxidants of different chemical structure was studied. The highest inhibitory effect was observed with the use of antioxidants X-1 (a partially hydrated oxyquinoline) and P-1 (a polyaromatic nitrogen containing compound). The results of the study correlated with the data on nystatin and levorin. The stabilizing effect markedly depended on the temperature: with increasing of the temperature the antioxidant effect decreased. The spectrophotometric study revealed that the decrease of the biological activity of the antibiotic in the presence of the antioxidants was more pronounced than the change of its structure.