Vasilev D, Karadimov D
Khirurgiia (Sofiia). 1996;49(4):9-11.
Sepsis and septic shock continue to be the most common causes of death and multiple organ failure among patients in intensive care units. The standard therapeutic regimens include surgical removal of the source of sepsis, antimicrobial therapy, optimizing oxygenation, volume resuscitation, and treatment with catecholamines. The ever extending knowledge of the pathophysiological role played by cytokines and nitrous oxide in septic shock promote the efforts to control their synthesis and pharmacologic action in clinical situations. New therapeutic approaches have become available, including the administration of high doses immunoglobulins, monoclonal antibodies against endotoxin, pentoxilfyline and nitrous oxide inhibitors. Based on the encouraging findings, controlled clinical studies are undertaken to assay with precision their clinical efficacy.
脓毒症和脓毒性休克仍然是重症监护病房患者死亡和多器官功能衰竭的最常见原因。标准治疗方案包括手术切除脓毒症病灶、抗菌治疗、优化氧合、液体复苏以及使用儿茶酚胺进行治疗。人们对细胞因子和一氧化氮在脓毒性休克中所起病理生理作用的认识不断深入，这促使人们努力在临床情况下控制它们的合成和药理作用。新的治疗方法已经出现，包括给予高剂量免疫球蛋白、抗内毒素单克隆抗体、己酮可可碱和一氧化氮抑制剂。基于这些令人鼓舞的发现，开展了对照临床研究以精确测定它们的临床疗效。
