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氟伏沙明可减轻35%二氧化碳激发试验诱发的惊恐发作。

Fluvoxamine attenuates panic induced by 35% CO2 challenge.

作者信息

Pols H J, Hauzer R C, Meijer J A, Verburg K, Griez E J

机构信息

Department of Psychiatry and Neuropsychology, State University of Limburg, Maastricht, The Netherlands.

出版信息

J Clin Psychiatry. 1996 Nov;57(11):539-42. doi: 10.4088/jcp.v57n1107.

DOI:10.4088/jcp.v57n1107
PMID:8968304
Abstract

BACKGROUND

The authors investigated whether 6 weeks of treatment with fluvoxamine would decrease the anxiogenic response to the 35% CO2 challenge in 11 patients with DSM-III-R panic disorder with agoraphobia.

METHOD

The patients underwent a 35% CO2 challenge at baseline and again after 6 weeks of fluvoxamine treatment.

RESULTS

The anxiogenic effect of CO2 was significantly (p < .05) reduced during fluvoxamine treatment.

CONCLUSION

The results suggest a relationship between the anxiogenic effect of CO2 and the therapeutic effect of fluvoxamine.

摘要

背景

作者研究了氟伏沙明6周的治疗是否会降低11例患有广场恐怖症的DSM-III-R惊恐障碍患者对35%二氧化碳激发试验的致焦虑反应。

方法

患者在基线时接受35%二氧化碳激发试验，氟伏沙明治疗6周后再次接受该试验。

结果

在氟伏沙明治疗期间，二氧化碳的致焦虑作用显著降低（p < 0.05）。

结论

结果表明二氧化碳的致焦虑作用与氟伏沙明的治疗效果之间存在关联。

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