一种由狐青霉F-4148产生的新异棒曲霉素衍生物品曲霉素：分类学、分离、理化性质、结构及生物学特性
A new isopatulin derivative pintulin produced by Penicillium vulpinum F-4148 taxonomy, isolation, physico-chemical properties, structure and biological properties.
作者信息
Mikami A, Okazaki T, Sakai N, Ichihara T, Hanada K, Mizoue K
机构信息
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama.
出版信息
J Antibiot (Tokyo). 1996 Oct;49(10):985-9. doi: 10.7164/antibiotics.49.985.
PMID:8968391
Abstract
During our screening program of natural products from fungal metabolites for drugs effective against tumor cell lines, we discovered a new isopatulin derivative, pintulin, from the fermentation broth of Penicillium vulpinum F-4148. Pintulin shows weak activity against tumor cell lines, compared to that of adriamycin.
摘要
在我们对真菌代谢产物中的天然产物进行筛选以寻找抗肿瘤细胞系有效药物的过程中，我们从狐青霉F-4148的发酵液中发现了一种新的异棒曲霉素衍生物——品曲霉素。与阿霉素相比，品曲霉素对肿瘤细胞系显示出较弱的活性。
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