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一氧化氮影响多巴胺能过程。

Nitric oxide influences dopaminergic processes.

作者信息

Liu Y

机构信息

Department of Biochemistry, Jinan Medical College, Jinan University, Guangzhou, P. R. China.

出版信息

Adv Neuroimmunol. 1996;6(3):259-64. doi: 10.1016/s0960-5428(96)00021-6.

DOI:10.1016/s0960-5428(96)00021-6
PMID:8968425
Abstract

Nitric oxide, in recent years, has emerged as an important substance capable of modifying many biological processes. It is involved with both neural and immune processes. In my laboratory I will be examining the relationship of nitric oxide and its involvement with modifying dopaminergic processes. In this review, I examine reports that already document this relationship. Nitric oxide appears to be able to facilitate the release of various monoamines, especially dopamine. Furthermore, this gas has the ability to block the presynaptic re-uptake of dopamine as well. Taken together, it would appear that nitric oxide can prolong the "life' of dopamine in the synapse. Given the significance of dopamine in motor and psychological processes the significance of nitric oxide involvement increases exponentially.

摘要

近年来,一氧化氮已成为一种能够调节多种生物过程的重要物质。它参与神经和免疫过程。在我的实验室中,我将研究一氧化氮的关系及其与调节多巴胺能过程的关联。在这篇综述中,我研究了已经记录这种关系的报告。一氧化氮似乎能够促进各种单胺的释放,尤其是多巴胺。此外,这种气体也有能力阻断多巴胺的突触前再摄取。综上所述,一氧化氮似乎可以延长多巴胺在突触中的“寿命”。鉴于多巴胺在运动和心理过程中的重要性,一氧化氮参与的重要性呈指数级增长。

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