Boston P F, Dursun S M, Reveley M A
Department of Psychiatry, Faculty of Medicine, University of Leicester.
Br J Psychiatry. 1996 Dec;169(6):682-9. doi: 10.1192/bjp.169.6.682.
Cholesterol plays an important part in cellular structure and function and changes in serum levels may affect neurotransmission in the central nervous system.
A MEDLINE literature search was made covering the period 1990-95 with systematic searching of citations from the articles identified. Representative articles were selected, focusing on those aspects which had not been thoroughly reviewed elsewhere, namely suicidal ideation, depression, personality and schizophrenia.
Lowering cholesterol levels have been associated with an increase in violent deaths in cardiovascular primary prevention studies. However, altered cholesterol levels have also been reported in relation to other psychiatric disorders.
There is substantial evidence that serum cholesterol levels may be associated with variations in mental state or personality. Further work is needed to clarify this and to elucidate the mechanisms involved.
胆固醇在细胞结构和功能中起重要作用，血清水平的变化可能影响中枢神经系统的神经传递。
对1990 - 1995年期间的医学文献数据库（MEDLINE）进行检索，并对所识别文章的参考文献进行系统检索。挑选出具有代表性的文章，重点关注那些在其他地方未得到充分综述的方面，即自杀意念、抑郁、人格和精神分裂症。
在心血管疾病一级预防研究中，降低胆固醇水平与暴力死亡人数增加有关。然而，也有报道称胆固醇水平的改变与其他精神障碍有关。
有大量证据表明血清胆固醇水平可能与精神状态或人格的变化有关。需要进一步开展工作以阐明这一点并揭示其中涉及的机制。
