Yamada T, Okamoto M, Sueda T, Hashimoto M, Kajiyama G
Department of Cardiology, Hiroshima Prefectural Hiroshima Hospital.
Intern Med. 1996 Nov;35(11):844-8. doi: 10.2169/internalmedicine.35.844.
To elucidate the response of conductance and resistance vessels of the coronary artery after intracoronary isosorbide dinitrate (ISDN), we evaluated 11 patients with variant angina and 13 controls with a Doppler guidewire. Epicardial arterial diameter increased significantly after ISDN in patients with variant angina while it did not change significantly in the controls. Coronary diastolic flow velocity increased significantly in controls (p < 0.05), but was unchanged in patients with vasospastic angina. Coronary flow volume increased from 23.8 +/- 18.6 to 46.5 +/- 28.4 ml/min in patients with vasospastic angina as well as in the controls from 32.2 +/- 24.2 to 54.7 +/- 44.4 ml/min. Coronary resistance did not differ between the two groups before or after the injection of ISDN. Conductance vessels were dilated to a greater extent in the patients with variant angina. However, the response of resistance vessels did not differ significantly between the two groups.
为了阐明冠状动脉内注射硝酸异山梨酯（ISDN）后冠状动脉传导血管和阻力血管的反应，我们使用多普勒导丝评估了11例变异型心绞痛患者和13例对照者。变异型心绞痛患者注射ISDN后心外膜动脉直径显著增加，而对照组无显著变化。对照组冠状动脉舒张期流速显著增加（p < 0.05），但血管痉挛性心绞痛患者无变化。血管痉挛性心绞痛患者的冠状动脉血流量从23.8±18.6 ml/min增加到46.5±28.4 ml/min，对照组从32.2±24.2 ml/min增加到54.7±44.4 ml/min。注射ISDN前后两组冠状动脉阻力无差异。变异型心绞痛患者的传导血管扩张程度更大。然而，两组阻力血管的反应无显著差异。
