一名孤立性促肾上腺皮质激素缺乏患者出现严重贫血。

Severe anemia in a patient with isolated adrenocorticotropin deficiency.

作者信息

Ihara T, Tsujikawa T, Hodohara K, Inoue H, Fujiyama Y, Bamba T, Okabe H

机构信息

Second Department of Internal Medicine, Shiga University of Medical Science.

出版信息

Intern Med. 1996 Nov;35(11):898-901. doi: 10.2169/internalmedicine.35.898.

DOI:10.2169/internalmedicine.35.898

PMID:8968806

Abstract

A 64-year-old man was referred to our hospital for evaluation of progressive anemia. On admission, he had a severe normocytic normochromic anemia [hemoglobin 7.5 g/dl] requiring a blood transfusion. Endocrinological studies demonstrated an isolated ACTH deficiency. After receiving glucocorticoid replacement therapy, his anemia was rapidly corrected, his hematocrit and hemoglobin remained elevated for approximately 4 months. We present evidence that glucocorticoid plays an important role in the physiological regulation of human erythropoiesis.

摘要

一名64岁男性因进行性贫血被转诊至我院。入院时，他患有严重的正细胞正色素性贫血（血红蛋白7.5 g/dl），需要输血。内分泌学检查显示孤立性促肾上腺皮质激素（ACTH）缺乏。接受糖皮质激素替代治疗后，他的贫血迅速得到纠正，血细胞比容和血红蛋白在约4个月内一直保持升高。我们提供的证据表明，糖皮质激素在人类红细胞生成的生理调节中起重要作用。