绵羊血清和脑脊液中氯硝西泮的浓度。

Concentration of clonazepam in serum and cerebrospinal fluid of the sheep.

作者信息

Parry G J

出版信息

Pharmacology. 1977;15(4):318-23. doi: 10.1159/000136705.

Abstract

Following intravenous administration of clonazepam to sheep there was rapid equilibration of cerebrospinal fluid and unbound serum concentrations of the drug. The pharmacokinetics of clonazepam in sheep describe a 2-compartment model and the large volume of distribution suggests tissue binding of clonazepam. There was wide variation in serum concentration and at least 2 mg of clonazepam was necessary to attain the recommended therapeutic concentration.

摘要

给绵羊静脉注射氯硝西泮后，脑脊液和未结合的血清药物浓度迅速达到平衡。氯硝西泮在绵羊体内的药代动力学描述为二室模型，其较大的分布容积表明氯硝西泮与组织有结合。血清浓度存在很大差异，至少需要2毫克氯硝西泮才能达到推荐的治疗浓度。