给予锂盐加氟哌啶醇的大鼠体内锂的吸收、分布、清除及体温情况
Lithium absorption, distribution and clearance and body temperature in rats given lithium plus haloperidol.
作者信息
Smith D F, Shimizu M, Schou M
出版信息
Pharmacology. 1977;15(4):337-40. doi: 10.1159/000136708.
PMID:896950
Abstract
Renal lithium clearance, tissue lithium levels, serum lithium concentration, and body temperature were determined in rats given lithium alone or combined with haloperidol (0.5-1 mg/kg). A slight increase in serum lithium concentration occurred in one of the three groups given lithium plus haloperidol. Haloperidol failed to affect renal lithium clearance, tissue lithium levels and body temperature. The data do not support the hypothesis that haloperidol exerts an action on lithium pharmacokinetics.
摘要
在单独给予锂或锂与氟哌啶醇（0.5 - 1毫克/千克）联合给药的大鼠中，测定了肾锂清除率、组织锂水平、血清锂浓度和体温。在给予锂加氟哌啶醇的三组中的一组中，血清锂浓度略有升高。氟哌啶醇未能影响肾锂清除率、组织锂水平和体温。这些数据不支持氟哌啶醇对锂药代动力学有作用的假设。
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