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GELSTATS:一个使用VNTR多位点探针数据进行群体遗传学分析的计算机程序。

GELSTATS: a computer program for population genetics analyses using VNTR multilocus probe data.

作者信息

Rogstad S H, Pelikan S

机构信息

University of Cincinnati, OH, USA.

出版信息

Biotechniques. 1996 Dec;21(6):1128-31. doi: 10.2144/96216bc05.

Abstract

GELSTATS, a computer program for population genetics analyses utilizing genetic markers revealed with variable number tandem repeat (VNTR) multilocus probes, is described and made available (both as C++ source code and as an executable DOS program). The program calculates several population genetics parameters, including: (i) individual and population band numbers; (ii) population bands exhibiting complete linkage (redundant examples of such bands can be removed in subsequent analyses); (iii) similarity (fraction of bands shared) between individuals and average similarity within and between designated groups; (iv) estimated probability that two individuals chosen at random will have identical band profiles; (v) heterozygosity estimates for designated groups; and (vi) Fst estimates. Nonparametric permutation methods are used to assess the significance of differences in both within- and between-group similarity. A jackknife test for heterozygosity differences between groups is also computed. Examples of GELSTATS analyses illustrate some features of the program.

摘要

介绍了GELSTATS,这是一个利用可变数目串联重复(VNTR)多位点探针揭示的遗传标记进行群体遗传学分析的计算机程序,并提供了该程序(包括C++源代码和可执行的DOS程序)。该程序计算几个群体遗传学参数,包括:(i)个体和群体的条带数;(ii)表现出完全连锁的群体条带(此类条带的冗余示例可在后续分析中去除);(iii)个体之间的相似性(共享条带的比例)以及指定组内和组间的平均相似性;(iv)随机选择的两个个体具有相同条带图谱的估计概率;(v)指定组的杂合度估计值;以及(vi)Fst估计值。使用非参数置换方法来评估组内和组间相似性差异的显著性。还计算了组间杂合度差异的刀切检验。GELSTATS分析的示例说明了该程序的一些特点。

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